Thursday, October 24, 2013

This Fleet-Footed New Robot Walks Exactly Like You Do

One of the biggest challenges that engineers have faced in their quest to build a humanoid robot is one of the simplest tasks for humans: walking. More specifically, they've had a hard time engineering a robot to take strides and roll each foot heel-to-toe, like we do. Until now, that is.

Read more...


    






Source: http://feeds.gawker.com/~r/gizmodo/full/~3/nXSY3I0VW_Q/this-fleet-footed-new-robot-walks-exactly-like-you-do-1451400529
Category: new orleans saints   The Blacklist   courtney stodden   reggie bush   National Dog Day  

Top Italian court sides with Loren in tax dispute




FILE - Italian actress Sophia Loren poses for photos at a red carpet event in Rio de Janeiro, Brazil, in this Tuesday, Nov. 27, 2012 file photo. Italy’s top court has handed the actress a victory in a nearly 40-year-long battle over back taxes. Rome-based Court of Cassation judges ruled on Wednesday Oct 23 2013 that the beauty icon was right when calculating tax owed on 1974 income. (AP Photo/Felipe Dana, file)





ROME (AP) — Sophia Loren once served time in an Italian jail for tax evasion. Now Italy's top court has handed the actress a victory in a nearly 40-year-long battle over back taxes.

The Rome-based Court of Cassation ruled Wednesday the beauty icon was right when calculating tax owed on her 1974 income. Loren's tax experts, applying one of Italy's not-infrequent tax amnesties, calculated that she owed tax on 60 percent of her income that year, but tax officials insisted she should have paid tax on 70 percent of her taxable income. The top court decided that Loren was right.

In separate tax dispute, Loren voluntarily returned to Italy in 1982 to be jailed, serving 17 days of a 30-day sentence for tax evasion. She said then her deceased tax preparer had erred.

Source: http://news.yahoo.com/top-italian-court-sides-loren-tax-dispute-192304711.html
Category: apple   Once Upon A Time In Wonderland   Tom Clancy   Prisoners   Brickyard 400  

Cancer wasting due in part to tumor factors that block muscle repair, study shows

Cancer wasting due in part to tumor factors that block muscle repair, study shows


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23-Oct-2013



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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center





COLUMBUS, Ohio A new study reveals that tumors release factors into the bloodstream that inhibit the repair of damaged muscle fibers, and that this contributes to muscle loss during cancer wasting. The condition, also called cancer cachexia, accompanies certain types of cancer, causes life-threatening loss of body weight and lean muscle mass, and is responsible for up to one-in-four cancer deaths. There is no treatment for the condition.


The study was led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), and it points to new strategies and new drug targets for treating cancer cachexia.


The findings were published in the Journal of Clinical Investigation.


The researchers looked at muscle stem cells, which are also called satellite cells. These cells are associated with muscle fibers and are essential for repairing damaged fibers. Normally, damage to muscle fibers causes these stem cells to proliferate and to differentiate into mature muscle cells. These muscle cells then fuse with damaged surrounding fibers to limit muscle wasting. This process is blocked during cancer cachexia, the researchers say.


"Our study showed that although muscle stem cells are activated during cachexia, factors released by the tumor block these cells from differentiating into muscle cells, which leaves them unable to repair cachectic muscle fibers," says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and a member of the OSUCCC James Molecular Biology and Cancer Genetics Program.


"By identifying agents that overcome the block and allow muscle stem cells to differentiate, it might be possible to restore muscle mass and enhance the quality of life of cancer patients with cachexia," he says.


For this study, Guttridge and his colleagues used animal models and tissue from cachectic pancreatic-cancer patients to identify factors in the muscle microenvironment that contribute to cancer cachexia. Key findings include:

  • Cachexia is associated with tumor-induced damage to skeletal muscle cells and tumor-induced proliferation of muscle stem cells;
  • Overexpression of the muscle stem cell factor, Pax7, blocks the cells' ability to differentiate and promotes cancer-induced wasting;
  • The overexpression of Pax7 promotes cancer wasting by blocking the maturation of muscle cells and their fusion with surrounding fibers, which allows muscle to gain mass;
  • The overexpression of Pax7 is controlled by NF-kappa B (NF-kB), which has been shown to play multiple roles in cancer. In cachexia, NF-kB causes the deregulation of Pax7 expression, which in turn impairs differentiation of muscle progenitor cells and promotes muscle atrophy;
  • Because of its tissue specificity, Pax7 inhibition might offer an attractive therapy for cancer cachexia.

"For decades, studies in cachexia have focused on mechanisms that lead to muscle wasting from within skeletal muscle fibers," Guttridge says. "Our study is the first to show proof of concept that events occurring outside the muscle fiber and within the muscle microenvironment also play a part in driving muscle wasting in cancer."


###


Funding from the National Institutes of Health(NIH)/National Cancer Institute (grants CA097953, CA098466, CA124692) and the NIH/Center for Clinical and Translational Science (grant UL1TR000090) supported this research.


Other researchers involved in this study were first author Wei He, Jingxin Wang, Mark Bloomston, Peter Muscarella, Peter Nau, Nilay Shah, Matthew E.R. Butchbach and Katherine Ladner, The Ohio State University; Emanuele Berardi, Veronica M. Cardillo, Paola Aulino, Sergio Adamo, Dario Coletti, Sapienza University, Rome, Italy; Swarnali Acharyya, Memorial Sloan Kettering Cancer Center; Jennifer Thomas-Ahner, Federica Montanaro, Nationwide Children's Hospital; Michael A. Rudnicki, Ottawa Health Research Institute, Ottawa, Ontario, Canada; Charles Keller, Oregon Health and Science University.


The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only four centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 228-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top cancer hospitals in the nation as ranked by U.S.News & World Report.




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Cancer wasting due in part to tumor factors that block muscle repair, study shows


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PUBLIC RELEASE DATE:

23-Oct-2013



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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center





COLUMBUS, Ohio A new study reveals that tumors release factors into the bloodstream that inhibit the repair of damaged muscle fibers, and that this contributes to muscle loss during cancer wasting. The condition, also called cancer cachexia, accompanies certain types of cancer, causes life-threatening loss of body weight and lean muscle mass, and is responsible for up to one-in-four cancer deaths. There is no treatment for the condition.


The study was led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), and it points to new strategies and new drug targets for treating cancer cachexia.


The findings were published in the Journal of Clinical Investigation.


The researchers looked at muscle stem cells, which are also called satellite cells. These cells are associated with muscle fibers and are essential for repairing damaged fibers. Normally, damage to muscle fibers causes these stem cells to proliferate and to differentiate into mature muscle cells. These muscle cells then fuse with damaged surrounding fibers to limit muscle wasting. This process is blocked during cancer cachexia, the researchers say.


"Our study showed that although muscle stem cells are activated during cachexia, factors released by the tumor block these cells from differentiating into muscle cells, which leaves them unable to repair cachectic muscle fibers," says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and a member of the OSUCCC James Molecular Biology and Cancer Genetics Program.


"By identifying agents that overcome the block and allow muscle stem cells to differentiate, it might be possible to restore muscle mass and enhance the quality of life of cancer patients with cachexia," he says.


For this study, Guttridge and his colleagues used animal models and tissue from cachectic pancreatic-cancer patients to identify factors in the muscle microenvironment that contribute to cancer cachexia. Key findings include:

  • Cachexia is associated with tumor-induced damage to skeletal muscle cells and tumor-induced proliferation of muscle stem cells;
  • Overexpression of the muscle stem cell factor, Pax7, blocks the cells' ability to differentiate and promotes cancer-induced wasting;
  • The overexpression of Pax7 promotes cancer wasting by blocking the maturation of muscle cells and their fusion with surrounding fibers, which allows muscle to gain mass;
  • The overexpression of Pax7 is controlled by NF-kappa B (NF-kB), which has been shown to play multiple roles in cancer. In cachexia, NF-kB causes the deregulation of Pax7 expression, which in turn impairs differentiation of muscle progenitor cells and promotes muscle atrophy;
  • Because of its tissue specificity, Pax7 inhibition might offer an attractive therapy for cancer cachexia.

"For decades, studies in cachexia have focused on mechanisms that lead to muscle wasting from within skeletal muscle fibers," Guttridge says. "Our study is the first to show proof of concept that events occurring outside the muscle fiber and within the muscle microenvironment also play a part in driving muscle wasting in cancer."


###


Funding from the National Institutes of Health(NIH)/National Cancer Institute (grants CA097953, CA098466, CA124692) and the NIH/Center for Clinical and Translational Science (grant UL1TR000090) supported this research.


Other researchers involved in this study were first author Wei He, Jingxin Wang, Mark Bloomston, Peter Muscarella, Peter Nau, Nilay Shah, Matthew E.R. Butchbach and Katherine Ladner, The Ohio State University; Emanuele Berardi, Veronica M. Cardillo, Paola Aulino, Sergio Adamo, Dario Coletti, Sapienza University, Rome, Italy; Swarnali Acharyya, Memorial Sloan Kettering Cancer Center; Jennifer Thomas-Ahner, Federica Montanaro, Nationwide Children's Hospital; Michael A. Rudnicki, Ottawa Health Research Institute, Ottawa, Ontario, Canada; Charles Keller, Oregon Health and Science University.


The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only four centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 228-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top cancer hospitals in the nation as ranked by U.S.News & World Report.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/osuw-cwd102313.php
Category: remembering 9/11   US News college rankings   twerking   FXX   teresa giudice  

Is TrueCrypt truly secure? Let's have a fundraiser to find out



TrueCrypt is one of the most widely used disk-encryption applications in the world. But though it's open source, it's never had its security or features -- or its precompiled binaries -- audited thoroughly.


But now cryptography researchers Kenneth White and Matthew Green have decided to raise the money to have TrueCrypt's source code thoroughly audited by disinterested third parties. The results of the audit will be tracked on the website IsTrueCryptAuditedYet.com. (The answer thus far: No.)


Kicking off with a fundraiser on Indiegogo and a complementary one on FundFill, the two have thus far raised some $46,000 -- with 53 days left to go in the Indiegogo campaign.


Of all the encryption or security software out there with source code available, why audit TrueCrypt? Green puts it this way: "There's a shortage of high-quality and usable encryption software out there. TrueCrypt is an enormous deviation from this trend. It's nice, it's pretty, it's remarkably usable."


But the problems with TrueCrypt, especially in the post-Snowden age, are many and unnerving. For one, while some folks have looked at the source code, there's never been a really systematic, rigorous analysis of the program by professional cryptographers.


The Ubuntu Privacy Group did conduct its own analysis of the program's behavior, and while it didn't find anything that looked like an obvious backdoor, the group did find strange discrepancies in the way TrueCrypt works on different platforms, along with a possible attack on the way keyfiles are used. (They didn't find anything that looked like a backdoor, though.)


Second, since most people use the precompiled binaries of the program rather than generating the program from source code, there's speculation about whether the binaries offered at TrueCrypt's site are trustworthy. The program is also not easy to compile from its source code, as a number of people have discovered.


Finally, and maybe most important, no one knows who actually wrote the program.


The creators might well be taking pains to hide their identities to avoid being harassed, which makes sense. There might well be people foolish enough to think that threatening the creators of the program would be a way to get them to disclose a weakness in the software and thus compromise every TrueCrypt volume on the planet. (Unlikely.)


Still, as Green puts it, "I would feel better if I knew who the TrueCrypt authors were."


The audit proposed by Green and White covers four points: Have the source code audited by a professional outfit qualified to do such work; have a lawyer analyze the terms of the source code license used by TrueCrypt, which is not considered to be a true open source license due to some of its terms; pay out bounties for any bugs found in the code; and create binaries that can be verified against the source code.


Open source code is generally considered easier to secure than closed source code, but that doesn't mean open source code is automatically more secure -- it just means the auditing process is easier to conduct. Expertise is still needed -- and in the real world, expertise worth having is worth buying.


This story, "Is TrueCrypt truly secure? Let's have a fundraiser to find out," was originally published at InfoWorld.com. Get the first word on what the important tech news really means with the InfoWorld Tech Watch blog. For the latest developments in business technology news, follow InfoWorld.com on Twitter.


Source: http://www.infoworld.com/t/encryption/truecrypt-truly-secure-lets-have-fundraiser-find-out-229254?source=rss_infoworld_blogs
Category: mariano rivera   Phillip Lim Target   floyd mayweather   Zayn Malik   david cassidy  

Boston Marathon suspect may pin blame on brother

FILE - This file photo released Friday, April 19, 2013 by the Federal Bureau of Investigation shows Dzhokhar Tsarnaev, surviving suspect in the Boston Marathon bombings. Lawyers for Tsarnaev will ask a judge to address the death penalty protocol during a status conference in federal court Monday, Sept. 23, 2013, in Boston. Tsarnaev is accused in two bombings that killed three people and injured more than 260 others near the finish line of the April 15 marathon. (AP Photo/Federal Bureau of Investigation, File)







FILE - This file photo released Friday, April 19, 2013 by the Federal Bureau of Investigation shows Dzhokhar Tsarnaev, surviving suspect in the Boston Marathon bombings. Lawyers for Tsarnaev will ask a judge to address the death penalty protocol during a status conference in federal court Monday, Sept. 23, 2013, in Boston. Tsarnaev is accused in two bombings that killed three people and injured more than 260 others near the finish line of the April 15 marathon. (AP Photo/Federal Bureau of Investigation, File)







This May 4, 2013 police mugshot provided by the Orange County Corrections Department in Orlando, Fla., shows Ibragim Todashev after his arrest for aggravated battery in Orlando. Todashev, who was being questioned in Orlando by authorities in the Boston bombing probe, was fatally shot Wednesday, May 22, 2013 when he initiated a violent confrontation, FBI officials said. According to a filing made Monday, Oct. 23, 2013, Ibragim Todashev told investigators that Tamerlan Tsarnaev, the slain Boston Marathon bombing suspect, participated in a triple killing in Waltham, Mass. on Sept. 11, 2011. (AP Photo/Orange County Corrections Department)







(AP) — Dzhokhar Tsarnaev's lawyers may try to save him from the death penalty in the Boston Marathon bombing by arguing he fell under the murderous influence of his older brother, legal experts say.

The outlines of a possible defense came into focus this week when it was learned that Tsarnaev's attorneys are trying to get access to investigative records implicating the now-dead brother in a grisly triple slaying committed in 2011.

In court papers Monday, federal prosecutors acknowledged publicly for the first time that a friend of Tamerlan Tsarnaev told investigators that Tamerlan participated in the unsolved killings of three men who were found in a Waltham apartment with their throats slit, marijuana sprinkled over their bodies.

The younger Tsarnaev's lawyers argued in court papers that any evidence of Tamerlan's involvement is "mitigating information" that is critical as they prepare Dzhokhar's defense. They asked a judge to force prosecutors to turn over the records.

Dzhokhar Tsarnaev, 20, faces 30 federal charges, including using a weapon of mass destruction, in the twin bombings April 15 that killed three people and injured more than 260. Tamerlan Tsarnaev, 26, died in a gunbattle with police days later.

The government is still deciding whether to pursue the death penalty for the attack, which investigators say was retaliation for the U.S. wars in Muslim lands.

Richard Dieter, executive director of the Death Penalty Information Center, said the defense may be trying to show that the older brother was the guiding force.

"If I was a defense attorney and was seeking perhaps to draw attention to the influence the older brother had in planning the bombing, I would use his involvement in other crimes to show that he was likely the main perpetrator in the Boston bombing," Dieter said.

"I would take the position that my client, the younger brother, was strongly influenced by his older brother, and even if he is culpable, the death penalty is too extreme in this case."

Similarly, Aitan D. Goelman, who was part of the legal team that prosecuted Oklahoma City bombing figures Timothy McVeigh and Terry Nichols, said the defense may be looking to minimize the younger brother's role in the bombing.

"I think the most likely reason is that if they are arguing some kind of mitigation theory, that the older brother was a monster and the younger brother was under his sway or intimidated or dominated by him," he said.

Miriam Conrad, Tsarnaev's public defender, had no comment.

Investigators have given no motive for the 2011 slayings. One victim was a boxer and friend of Tamerlan Tsarnaev's.

Friends of those killed have said they gave Tsarnaev's name to investigators at the time. That has raised questions of whether authorities missed an opportunity to prevent a bigger tragedy.

Federal prosecutors said in court papers that Ibragim Todashev, another friend of Tamerlan's, told authorities that Tamerlan took part in the killings. Todashev was shot to death in Florida in May by authorities while being questioned.

Prosecutors argued that turning over the records would damage the investigation into the killings.

___

Smith reported from Providence, R.I. Associated Press writer Pete Yost in Washington contributed to this report.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-10-23-US-Boston-Marathon-Bombing/id-68a69619519c4562b33983dbc7660bc0
Tags: Windows 8.1   Nintendo 2DS   Shawn Burr   yemen   Nexus 7  

Ku? Poa? Buena onda?


What Cool Looks Like Around the World



In America we have at least a passing idea of what's "cool" to us today, even if a singular definition
is forever eluding us. But what does it look like in other corners of the world? As with all discussions of cool, this does not attempt to be a
comprehensive or conclusive definition of coolness-but rather a snapshot of the concept as perceived outside of the U.S. So here's to being ku, buena onda, or poa—and remember that no matter what anyone else may say, cool can be found pretty much anywhere.




Feiyue. GOU YIGE/AFP/Getty Images



Ku in China



A recent study on China's "Red Cool" by TBWA/China, an international ad agency,
found that "zheng neng liang" (meaning "positive energy") is a popular notion among Chinese youth today. TBWA/China's research suggests that being positive
and aspirational are considered cool traits among youth. "Real 'cool' is to bring [your] dreams to reality and make them perfect," one young adult explains
in the study. "No one should compromise on the way to realizing a dream."



To a perhaps unsurprising extent, in China the monoculture still exists, so being different is often not seen as ku. The things that are
cool—or at least highly consumed—include Starbucks ("an indication that they've reached a certain status," says Shaun Rein, managing director of China Market Research Group) and
Adidas' NEO line. On the home front, Rein reports that the Chinese-made JDB, an herbal tea, outsells Coke and Pepsi in many parts of the country whileFeiyue shoes have been a hit for hip urban types. The iPhone isn't cool, apparently; Apple's
phone has lost sway with mainstream Chinese consumers as of late. (This may in part have to do with there being only eight store locations in the entire
country, according to Rein.)



Interestingly, Chinese coolness is heavily influenced by South Korea: It can
be found in nearly every form of Chinese consumerism—movies, TV, fashion, and especially pop music. Long before Psy introduced K-pop to the Western world,
South Korean culture was dominant across Asia, thanks to Korea's realization that it could find success by exporting culture
and investing millions of dollars in arts and entertainment.




Justin Bieber and Drake. George Pimentel/WireImage



Cool in Canada



Despite Drake's best efforts, Canada has rarely been seen as cool; it ranked fourth in a 2011 poll of the least-cool nationalities (just slightly cooler than Belgians, Poles,
and Turks). In fact, Canadians revel in their perceived out-of-touch-ness: "Canada might not be one of the coolest countries in the world but it is one of
the most civilized," said Lloyd Price, at the time the marketing director of social-networking site Badoo, in response to the poll results. "Like the
Queen, Canada is so uncool, it's cool. And proud of it."



In fact, cool in Canada has less to do with brands, rebellious teenagers, and subversive countercultures, and more to do with altruism. In a study published in 2012, researchers found that their predominantly female
sample of "mostly educated" young Canadians associated "friendliness" most often with characteristics of coolness. ("Personal competence" and the more
expected "trendiness" followed closely behind.)



Also consider the finalists in a recent " Canada is Cool"
photo contest sponsored by the Embassy of Canada in Belgium: "Canada is cool, because I love the way people live with each other and how Canadians respect
the wildlife and there (sic) habitat!" reads one caption. And another: "I think this photograph represents Canada as a
whole: love, friendship, sunshine (in the figurative sense)." In Canada, it's hip to be square.




Takashi Murakami. Wikimedia Commons



Sugoi in Japan



Once upon a time, Japanese cool was a masculine quality—studiousness was prized, and warriors were lionized. But as noted by scholars

Christine R. Yano

, Tomoyuki Sugiyama, and others, "cuteness," or kawaii, has taken center stage in Japan, as seen in the global success of Hello Kitty, as well
as J-Pop and the trendy, youth-oriented Tokyo district Harajuku.



Yet while the emergence of the aforementioned adorable cat, along with manga comics, anime, and the influential superflat art movement have Japanese roots, there is still some sense
that Western influence must be present in order for Japanese exports to be considered cool. In 2002 Doug McGray coined the country's creative efforts as " Japan's gross national cool" and observed that foreign influence
was practically essential to being hip, whether it was culturally accurate or not: A "whiff of American cool" from U.S. imports (like potato salad pizza,
he suggests) and a "whiff of Japanese cool" in exports (cream cheese-and-salmon sushi) are an indicator of what can be fashionable in Japan.



Today Japan is one of the most aggressive countries in the world when it comes to cultivating and exporting cool: The Ministry of Economy, Trade, and
Industry spends millions on its "Cool Japan" PR initiative, in
order to amplify the nation's "soft power." After some blunders, the METI now believes that
in order to be successful, it must look to international influence less, and "use Japanese content to sell Japanese products." It's unclear when that will
change, however—for now at least, the "Cool Japan" funding doesn't appear to be going to the people working domestically in poor conditions and for little
pay; and some artists find the government's PR initiative to be nothing short of uncool.




Mario Tama/Getty Images



Legal in Brazil



A "feel-good" vibe encompasses nearly every cultural aspect of Brazil, as one native explains. And there are many of them: Because Brazil is made up of
such a sprawling, diverse population, what's legal depends on a variety of different tastes and sensibilities. When it comes to music, anything
currently popular abroad will likely be hip there, but the country also has its own cool and hugely popular genres: explicit, sexualized "funk" music (dubbed "the sound of the people," as the upper class tends to ignore it) and sertanejo (Brazil's rendition of country music).



In recent years, the " small step battle," in which kids
post videos of themselves performing intricate dance steps and then challenge others to come up with something even better, has grown in popularity. And
underprivileged kids are also finding a voice through graffiti, which was legalized in Brazil in 2009. And there's always sports: As one
Brazilian native tells me, "There's an almost tangible sensation that what's 'cool' in Brazil is whatever's healthier for you." Thus the many ads (and sometimes, song lyrics)
that rave about the tropical climate and urge people to participate in physical activity—be it fútbol, hiking, samba dancing, or going to the beach.




TARTU, ESTONIA: Young Estonian boys play footbag (hacky sack) during a winter's night in the main street of Tartu early 07 January 2005. This alternative sport is becoming increasingly popular among Estonia's youth. JANEK SKARZYNSKI/AFP/Getty Images




Cool in Estonia



It's only in recent years that the Baltic states have seen prosperity; after gaining independence in the 1990s, the region was extremely poor, and the
cultural notion of "cool" wasn't an issue of concern, as a recent resident of Latvia explains to me. But the economy has since improved, especially in Estonia, and what's hip now is not so different from what's hip in the West.



American and European cultures are very much integrated into the Baltics. Electronic music is still big in underground clubs, and while Estonia has a small
indie/alternative scene, native acts generally won't be deemed cool until they've first gained popularity elsewhere. The Swedish-owned retail company
H&M just opened its first store in Estonia in September, and Zara is popular as well.



Hipsters also exist, and one Estonian's description of such a person you might see there sounds eerily similar to Brooklyn's typical export: Thin, "highly
emotional" young males adorned in skinny jeans and cardigans, perhaps accompanied by a bike. However, while American hipsters tend to be as old as their
mid-30s, in Estonia, those in their mid-20s and above tend to ditch the fashion trend.



One thing that separates Estonia from the West is sensibility—while young Americans tend to be extremely conscious of irony (think of the incredibly
self-aware hipster mustache), most people in the Baltic region are multilingual, and so shades of meaning can be lost in inter-lingual conversation.
Instead, one appears as she wishes to appear to others; if you dress like a hipster, you do so because you simply think it's cool, not to make an ironic
statement.




Salman Khan. Wikimedia Commons



Cool in India



Earlier this year, the Times of India posed the evergreen question: " What's cool?" The article featured
a curious mix of responses and pull quotes from prominent Indian figures like singer Shefali Alvares and, uh, Taylor Swift. But the most interesting answer
came from columnist Palash Krishna Mehrotra: "How can [Indians] be genuinely cool when we are always so eager to please?" he wondered. " 'Coolness'
involves doing your own thing without thinking what others will think of you."



Maybe. As a general rule in India, most things connected to Western culture may be considered cool. But there are at least two viewpoints on what's truly
hip in India, as one native now living in the U.S. explains to me: the small-town point of view, and the big-city one. With the former, Western culture can
be somewhat idolized, as primary exposure to such things is via television; coffee shops (an icon of leisure and prosperity rarely found outside urban
communities) and iPhones are admired by younger people. (And Hollywood is cooler than Bollywood.) When it comes time for college, many will seek out the
majors that are the most likely to get them jobs in the U.S.



In the city it can be quite different. Young urban people tend to have more money, so their exposure to Western culture often comes from trips abroad.
Often, they return to India feeling more appreciative of their own country's culture, or even are more inclined to take vacations and backpacking trips
within India itself.




Daniel Craig. Andreas Rentz/WireImage




Brilliant in the U.K.



As one Brit living in the U.S. explains it, "Generally, the British psyche is not to try too hard. Ever. God forbid you're earnest. We don't deal well with
that." That's one reason why, when compared with America, high school and college athletes aren't nearly as idolized as they are here, and there's less of
a culture built around jocks (and people who want to sleep with jocks). And while there's definitely great national pride for those who domake it
big—see the U.K.'s success at the 2012 Olympics—obsessing over sports "would require
trying really hard."



Currently, the documentary TV series Educating Yorkshireis having a
moment, resonating especially with teenagers. The show, which follows several Yorkshire teens at a troubled school rife with ethnic and class tension,
reached more than 4 million people
for its premiere last month. And the students at the center of Educating Yorskshire have become celebrities in their own right—one of them,
Bailey, who sports hand-drawn eyebrows, has inspired a catchphrase: "D'you like me eyebrows? I shaved 'em all off."




AFP PHOTO/Tony KARUMBA



Poa in Kenya



Sheng, a language combining Swahili and English (along with other Kenyan dialects) that first emerged in Nairobi in the 1970s, has come to dominate the way
in which young people in Kenya communicate with one another. What was once a language associated primarily with thugs and Nairobi youth who wished to evade the law and their parents, respectively,
has now spread throughout the entire country, appearing in hip-hop as well as literary publications targeted at Kenyans under 30.



One such publication is Shujaaz.fm, a monthly comic book distributed monthly through the Daily Nation. Shujaaz ("heroes" in Sheng), centers on a 19-year-old kid who, unable to find a job after finishing school, creates his own radio show under an
alter ego. (The show airs on real FM stations across the country.) The comic educates youth about everything from agriculture to political activism, and
though solid numbers are hard to come by, the head of the consultant agency behind the project has claimed that Shujaaz reaches about 5 million Kenyans between 10 and 25 years
old monthly.



On a smaller scale, a tiny contingent of Kenyans—an estimated 300 in Nairobi—have adopted
their own version of goth culture. Typically adorned in black, tattoos, and piercings, Kenyan goths are often stared at and sometimes ridiculed, as many
people perceive them to be violent drug abusers based primarily on their attire. (Many older goths are actually practicing Christians, and many stories of
crimes committed by goths are unsubstantiated, according to Think Africa Press.) Because of this, some prefer to don the aesthetic only when
within "the safety that comes in numbers."




Young people practice parkour in a tunnel used as a track under one of the busiest highways in Mexico City on 24 May, 2012. The government of the Mexican capital created the free space for young people to practice different sports disciplines with trainers from the Youth's Institute of Mexico city. OMAR TORRES/AFP/GettyImages



Buena onda in Mexico



Much of Mexico's youth culture is characterized by resistance against poor living conditions and difficult police-citizen relationships through cultural
expression, especially through music and fashion. As Daniel Hernandez, who chronicled several Mexican subcultures in his book Down and Delirious in Mexico Citywhile living in the nation's capital
(where half the population is under 25) for several years, has put it: "It's hard to live here,
so that makes good youth culture."



In Condesa, a Mexico City district, to be a hipster is to be "as eclectic as possible" when it comes to personal taste, Hernandez observed in his book.
Sartorial display is held in high regard, with young designers creating daring designs and "clothes meant for partying." And unlike Brooklyn's hipsters,
most hipster Mexicans don't idealize the struggling artist or craftsman persona, but rather aspire to upper-middle-class life in the likes of Coyoacán
or Del Valle.



The punk, goth, and ska movements that emerged in the 1980s still remain (though as Hernandez writes in his book, the youth reject clear-cut terminologies
as descriptors of their identity), and the El Chopo marketplace in Mexico City is
where all of these groups and others convene on a weekly basis. Here, " the plaza and the family are central,
not the individual."



And in Ciudad Juárez—once known for being the " deadliest city in the world"—"nueva ola fronteriza" ("new border
wave") has arisen in opposition to the
once-popular narcocorrido genre of music, which glorifies drug cartels and violence. The glorified ballads of Los Tigres del Norte and other performers
are now considered passé to much of Mexican youth-and nueva ola fronteriza bands like Pájaro Sin Alas (Bird Without Wings), who sing songs with peaceful messages influenced by
tropical rhythms and Latin pop genres, are emerging as positive
alternatives.




Xander Ferreira and Nick Matthews aka DJ Invisible of the South African band Gazelle (Stocktown)



Befok in South Africa



Today's South African youth are known as the "born free" generation-those born after the end of apartheid and election of Nelson Mandela in 1994. As poet
Lebo Mashile-who, while older, is said to be a voice for the born-frees- has explained it: "Being a born-free means that I experience the
legacies of apartheid, you know. But it also means that I have access to opportunities."



Because of this, as well as South Africa's status as one of the

most unequal countries

in the world, youth maintain an especially complex identity. Johannesburg has been a leader in creativity and identity shaping for youth despite the gaping
disparities between the very poor and the wealthy, and heavy political unrest; art studios, fashion, and music have thrived in the city in recent
years-leading some to compare it to Brooklyn. And there are
variants of cool to be found there: Some black youth, for instance, reject the notion of Western stereotypes of African dress, choosing to go for more
muted styles; others, like the internationally known Smarteez fashion crew, borrow from both
African and Western style unabashedly.



In recent years a backlash has developed against the nation's staunch income inequality. A growing subculture known as izikhothane (Zulu for "to lick," but which has now
come to mean "bragging") has created a ritual that involves buying expensive clothing and accessories and destroying the items after using them only once.
The youths, most of them poor and/or unemployed, then document their work online. "

Destroying symbols of value

gives them recognition and status," one Sowetan explained to the Guardian,"and that is what they crave-much more than money. The bigger
the display of abundance and your ability to destroy it, the bigger your 'swag,' and that's what matters to them most."


Source: http://www.slate.com/articles/life/cool_story/2013/10/what_s_cool_in_china_south_africa_brazil_and_elsewhere_around_the_world.html
Category: Josh Freeman   yosemite national park   Lane Kiffin   Kerry Washington   Angel Dust  

Imaging breast cancer with light

Imaging breast cancer with light


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23-Oct-2013



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Contact: Lyndsay Meyer
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The Optical Society



Netherlands researchers unveil their 'photoacoustic mammoscope,' a new device that could someday be used for routine breast cancer screenings




WASHINGTON, Oct. 23, 2013 -- Breast cancer is one of the most common forms of cancer and cancer deaths among women worldwide. Routine screening can increase breast cancer survival by detecting the disease early and allowing doctors to address it at this critical stage. A team of researchers at the University of Twente in the Netherlands have developed a prototype of a new imaging tool that may one day help to detect breast cancer early, when it is most treatable.


If effective, the new device, called a photoacoustic mammoscope, would represent an entirely new way of imaging the breast and detecting cancer. Instead of X-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The researchers describe their device in a paper published today in The Optical Society's (OSA) open-access journal Biomedical Optics Express.


A 3-D Map of the Breast


In the new technique, infrared light is delivered in billionth-of-a-second pulses to tissue, where it is scattered and absorbed. The high absorption of blood increases the temperature of blood vessels slightly, and this causes them to undergo a slight but rapid expansion. While imperceptible to the patient, this expansion generates detectable ultrasound waves that are used to form a 3-D map of the breast vasculature. Since cancer tumors have more blood vessels than the surrounding tissue, they are distinguishable in this image.



Currently the resolution of the images is not as fine as what can be obtained with existing breast imaging techniques like X-ray mammography and MRI. In future versions, Srirang Manohar, an assistant professor at the University of Twente who led the research, Wenfeng Xia, a graduate student at the University of Twente who is the first author on the new paper, and their colleagues expect to improve the resolution as well as add the capability to image using several different wavelengths of light at once, which is expected to improve detectability.


The Twente researchers, who belong to the Biomedical Photonic Imaging group run by Professor Wiendelt Steenbergen, have tested their prototype in the laboratory using phantoms -- objects made of gels and other materials that mimic human tissue. Last year, in a small clinical trial they showed that an earlier version of the technology could successfully image breast cancer in women.


Manohar and his colleagues added that if the instrument were commercialized, it would likely cost less than MRI and X-ray mammography.


"We feel that the cost could be brought down to be not much more expensive than an ultrasound machine when it goes to industry," said Xia.


The next step, they say, will be to prepare for larger clinical trials. Several existing technologies are already widely used for breast cancer screening and diagnosis, including mammography, MRI, and ultrasound. Before becoming routinely used, the photoacoustic mammoscope would have to prove at least as effective as those other techniques in large, multicenter clinical trials.



"We are developing a clinical prototype that improves various aspects of the current version of the device," said Manohar. "The final prototype will be ready for first clinical testing next year."


###


Paper: "Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography," W. Xia et al., Biomedical Optics Express, Vol. 4, Issue 11, pp. 2555-2569 (2013). http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-4-11-2555


EDITOR'S NOTE: Images and video footage are available to members of the media upon request. Contact Lyndsay Meyer, lmeyer@osa.org.


About Biomedical Optics Express


Biomedical Optics Express is OSA's principal outlet for serving the biomedical optics community with rapid, open-access, peer-reviewed papers related to optics, photonics and imaging in the life sciences. The journal scope encompasses theoretical modeling and simulations, technology development, and biomedical studies and clinical applications. It is published by The Optical Society and edited by Joseph A. Izatt of Duke University. Biomedical Optics Express is an open-access journal and is available at no cost to readers online at http://www.OpticsInfoBase.org/BOE.

About OSA


Founded in 1916, The Optical Society (OSA) is the leading professional society for scientists, engineers, students and business leaders who fuel discoveries, shape real-world applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership programs, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of professionals in optics and photonics. For more information, visit http://www.osa.org.


Contact:


Lyndsay Meyer

The Optical Society

+1.202.416.1435
lmeyer@osa.org


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Imaging breast cancer with light


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

23-Oct-2013



[


| E-mail

]


Share Share

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society



Netherlands researchers unveil their 'photoacoustic mammoscope,' a new device that could someday be used for routine breast cancer screenings




WASHINGTON, Oct. 23, 2013 -- Breast cancer is one of the most common forms of cancer and cancer deaths among women worldwide. Routine screening can increase breast cancer survival by detecting the disease early and allowing doctors to address it at this critical stage. A team of researchers at the University of Twente in the Netherlands have developed a prototype of a new imaging tool that may one day help to detect breast cancer early, when it is most treatable.


If effective, the new device, called a photoacoustic mammoscope, would represent an entirely new way of imaging the breast and detecting cancer. Instead of X-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The researchers describe their device in a paper published today in The Optical Society's (OSA) open-access journal Biomedical Optics Express.


A 3-D Map of the Breast


In the new technique, infrared light is delivered in billionth-of-a-second pulses to tissue, where it is scattered and absorbed. The high absorption of blood increases the temperature of blood vessels slightly, and this causes them to undergo a slight but rapid expansion. While imperceptible to the patient, this expansion generates detectable ultrasound waves that are used to form a 3-D map of the breast vasculature. Since cancer tumors have more blood vessels than the surrounding tissue, they are distinguishable in this image.



Currently the resolution of the images is not as fine as what can be obtained with existing breast imaging techniques like X-ray mammography and MRI. In future versions, Srirang Manohar, an assistant professor at the University of Twente who led the research, Wenfeng Xia, a graduate student at the University of Twente who is the first author on the new paper, and their colleagues expect to improve the resolution as well as add the capability to image using several different wavelengths of light at once, which is expected to improve detectability.


The Twente researchers, who belong to the Biomedical Photonic Imaging group run by Professor Wiendelt Steenbergen, have tested their prototype in the laboratory using phantoms -- objects made of gels and other materials that mimic human tissue. Last year, in a small clinical trial they showed that an earlier version of the technology could successfully image breast cancer in women.


Manohar and his colleagues added that if the instrument were commercialized, it would likely cost less than MRI and X-ray mammography.


"We feel that the cost could be brought down to be not much more expensive than an ultrasound machine when it goes to industry," said Xia.


The next step, they say, will be to prepare for larger clinical trials. Several existing technologies are already widely used for breast cancer screening and diagnosis, including mammography, MRI, and ultrasound. Before becoming routinely used, the photoacoustic mammoscope would have to prove at least as effective as those other techniques in large, multicenter clinical trials.



"We are developing a clinical prototype that improves various aspects of the current version of the device," said Manohar. "The final prototype will be ready for first clinical testing next year."


###


Paper: "Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography," W. Xia et al., Biomedical Optics Express, Vol. 4, Issue 11, pp. 2555-2569 (2013). http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-4-11-2555


EDITOR'S NOTE: Images and video footage are available to members of the media upon request. Contact Lyndsay Meyer, lmeyer@osa.org.


About Biomedical Optics Express


Biomedical Optics Express is OSA's principal outlet for serving the biomedical optics community with rapid, open-access, peer-reviewed papers related to optics, photonics and imaging in the life sciences. The journal scope encompasses theoretical modeling and simulations, technology development, and biomedical studies and clinical applications. It is published by The Optical Society and edited by Joseph A. Izatt of Duke University. Biomedical Optics Express is an open-access journal and is available at no cost to readers online at http://www.OpticsInfoBase.org/BOE.

About OSA


Founded in 1916, The Optical Society (OSA) is the leading professional society for scientists, engineers, students and business leaders who fuel discoveries, shape real-world applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership programs, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of professionals in optics and photonics. For more information, visit http://www.osa.org.


Contact:


Lyndsay Meyer

The Optical Society

+1.202.416.1435
lmeyer@osa.org


[ Back to EurekAlert! ]

[


| E-mail


Share Share

]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/tos-ibc102313.php
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